What does the intervillous space contain?
The intervillous space is simply the space between the mother’s blood vessels and the fetal chorionic villi. It is filled with a pool of maternal blood where bathe the villi. This is where all nutrient, gas and waste exchange occur.
Does cytotrophoblast give rise to syncytiotrophoblast?
The cytotrophoblast is cellular and expands mitotically into the syncytiotrophoblast to form primary chorionic villi.
What is found within the intervillous space of the human placenta?
This space of the placenta contains maternal blood, which is derived from the lacunae that developed in the syncytiotrophoblast during the second week of development (seeChapter 4,Fig.
Is Syncytium the same as syncytiotrophoblast?
As the outermost layer of all villi, the syncytiotrophoblast covers all placental villi as one single layer covering all villi of a single placenta. This layer is a true syncytium, developed and maintained by fusion of mononucleated cells and without any lateral cell borders (Benirschke et al., 2006).
How is intervillous space formed?
With this physiologic destructive process, the maternal blood vessels of the endometrium are opened, with the result that the spaces in the trophoblastic network are filled with maternal blood; these spaces communicate freely with one another and become greatly distended and form the intervillous space from which the …
Does intervillous space contains fetal blood?
This space of the placenta contains maternal blood, which is derived from the lacunae that developed in the syncytiotrophoblast during the second week of development (seeChapter 4,Fig. 4.1B).
Where does the syncytiotrophoblast come from?
The large multinucleated syncytiotrophoblast is formed by the fusion of underlying cytotrophoblasts, which facilitate its expansion as the placenta grows.
What does the cytotrophoblast differentiate into?
It is widely accepted that villous cytotrophoblasts from term placentae are committed to differentiate into syncytiotrophoblast (Morrish et al. 1997).
Where is the syncytiotrophoblast?
the human placenta
6.2. The syncytiotrophoblast, the outermost layer of the human placenta, is the main site of exchange for drugs and metabolites, nutrients, waste products, and gases between the maternal and fetal circulations.
What does the syncytiotrophoblast become?
syncytiotrophoblast the multinucleated trophoblast that forms the outer layer of the chorionic villi responsible for nutrient exchange and hormone production. The precursor cells of the human placenta—the trophoblasts—first appear four days after fertilization as the outer layer of cells of the blastocyst.
What is intervillous space in embryology?
In human embryology, intervillous space is the “space between the villi containing the vessels” of the mother and the embryo . The trophoblast, which is a collection of cells that invades the maternal endometrium to gain access to nutrition for the fetus, proliferates rapidly and forms a network…
What is the intervillous space?
Between the placental villi, exists a complicated system of intercommunicating spaces called the ‘intervillous space’ (Figure 5 ).
How many ml of blood are in the intervillous space?
Maternal arteries and veins directly enter the intervillous space after 8 weeks gestation, and the intervillous space will contain about a unit of blood (400–500 mL).
What cells are present in the intervillous space of infected placenta?
The intervillous spaces of infected placentas are packed with lymphoid macrophages, which contain phagocytosed pigment in large granules. Lymphocytes and immature polymorphonuclear leukocytes are also present in large numbers. Numerous young and mature schizonts are present.