What does CD138 positive mean?
CD138 is a classic plasma cell marker and can be found on both normal polyclonal or abnormal monoclonal plasma cells. Being CD138 positive and knowing the total plasma cell % from the core bone specimin would be the best markers to understand the extent of bone marrow infiltration.
Which cells express CD138?
Introduction. ]. In normal tissues, CD138 is known to be expressed on plasma cells and various epithelial cell types.
What does CD138 stain?
CD138 is expressed on plasma cells and can be useful in the diagnosis of plasma cell neoplasms. Epithelial cells and endothelial cells may also express CD138. In normal tonsil tissue, CD138 strongly stains the membranes of mature plasma cells and squamous epithelial cells.
Do Plasmablasts Express CD138?
Plasma cells at higher level (68) and pre-B cells at lower level (69) are the only hematopoietic cells that express CD138. High expression of CD138 on plasma cells is a hallmark of their identification, which is upregulated during differentiation from plasmablasts into plasma cells (69).
What is CD138 positive plasma cells?
During normal B-cell development, cells acquire expression of CD138, also known as syndecan-1 (SDC1), a marker highly specific for terminally differentiated normal plasma cells (1). CD138 is a heparin sulphate proteoglycan that controls tumor cell survival, growth, adhesion and bone cell differentiation in MM (2).
What is CD138 in multiple myeloma?
CD138 expression is a hallmark of plasma cells and multiple myeloma cells. However, decreased expression of CD138 is frequently observed in plasma cells of myeloma patients, although the clinical significance of this is unclear.
What is CD138 negative plasma cells?
CD138 negative plasma cells are a sub-population of malignant plasma cells (PCs) which may be more primitive and have a higher proliferative potential than CD138 positive plasma cells [1].
What does CD138 negative mean?
What is CD38 a marker for?
CD38 is a multi-functional transmembrane protein that is a lymphocyte receptor and a clinical marker for survival of patients with B-cell chronic lymphocytic leukemia (CLL) [1-5].
What is the difference between Plasmablasts and plasma cells?
The most immature blood cell that is considered of plasma cell lineage is the plasmablast. Plasmablasts secrete more antibodies than B cells, but less than plasma cells. They divide rapidly and are still capable of internalizing antigens and presenting them to T cells.
What are Plasmablasts?
In immunology, a “plasmablast” refers to a short-lived differentiation stage between a post germinal centre B-cell and a mature plasma cell. Plasmablasts retain a proliferative capability together with an almost fully mature plasma cell phenotype [1].
What is CD138 marker?
What is the SDC1 gene?
SDC1 (Syndecan 1) is a Protein Coding gene. Diseases associated with SDC1 include Mucinous Bronchioloalveolar Adenocarcinoma and Granulomatous Endometritis.
What is syndecan-1 U266?
Tissue, cells or virus corresponding to Syndecan-1. U266 cell line. This antibody stains all plasma cells and plasma cell lines. No staining of other leucocytes is seen in peripheral blood or bone marrow, although some ALL cell lines express the antigen weakly. Some staining of epithelial and endothelial cells may be seen in immunohistology.
Does this antibody stain all plasma cells?
This antibody stains all plasma cells and plasma cell lines. No staining of other leucocytes is seen in peripheral blood or bone marrow, although some ALL cell lines express the antigen weakly. Some staining of epithelial and endothelial cells may be seen in immunohistology.
Is CD138 a useful marker for normal and neoplastic syndecan-1?
Background. Altered syndecan-1 expression has been detected in several different tumor types. CD138 was regarded as a useful marker for labeling normal and neoplastic plasma cells and plasmacytoid lymphomas. CD138 has a calculated molecular weight of 32.5 kDa, the apparent molecular weight is higher due to extensive glycosylation.