Is HHV 8 DNA or RNA virus?
The Human Herpesvirus-8 (HHV-8), also called Kaposi sarcoma Herpesvirus (KSHV), belongs to the family of DNA viruses Herpeseviridae. It causes Kaposi sarcoma (a vascular malignancy) and B cell lymphoproliferative diseases such as primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD).
How is HHV8 diagnosed?
Laboratory diagnosis of HHV-8 infection is most commonly based on serologic assays, such as immunofluorescence, enzyme-linked immunosorbent assay, and Western blot. However, there is no gold standard for diagnosing HHV-8 infection. Serologic tests range in sensitivity from 80% to ≥90% and interassay agreement is poor.
What does HHV 8 stand for?
Human herpesvirus-8 (HHV8): human gammaherpesvirus, also known as Kaposi’s sarcoma herpesvirus (KSHV).
Can HHV 8 undergo latency?
HHV 8 infects dividing B cells. It then proceeds to either a lytic replication cycle, releasing infectious virus, or enters latency, expressing only the latency-associated nuclear antigens (LANAs).
Is human herpesvirus 8 contagious?
The mode(s) of transmission of HHV-8 remains unclear, but epidemiologic and virologic data suggest that saliva is a source of infectious virus and may be an important route of transmission. Asymptomatic HHV-8 infection is often associated with HHV-8 shedding in the saliva and occasional shedding in genital secretions.
Is HHV and HSV the same?
The human herpesvirus or herpes simplex virus (HHV or HSV) is a neurotropic virus that has two distinct serotypes, human herpesvirus 1 and 2 (HHV-1 and HHV-2). Although both viruses are closely related, they contain sufficient differences to enable type identification (Nicoll et al.
How is HHV diagnosed?
The diagnosis of HHV-6 infection is performed by both serologic and direct methods. The most prominent technique is the quantification of viral DNA in blood, other body fluids, and organs by means of real-time PCR.
How do you test for KSHV?
Infection with KSHV is diagnosed by a blood test and a number of research groups are trying to find the optimal method for virus detection.
Can HPV cause Kaposi sarcoma?
One explanation for this finding is that AIDS-KS may be caused by an infectious agent. Because there is a high incidence of human papillomavirus (HPV) infection, especially HPV-16, in homosexual men, we have sought HPV DNA sequences in Kaposi’s sarcoma.
What causes HSV 8?
Kaposi sarcoma (KS) is caused by infection with a virus called the Kaposi sarcoma–associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8). KSHV is in the same family as Epstein-Barr virus (EBV), the virus that causes infectious mononucleosis (mono) and is linked to several types of cancer.
What causes hsv1 reactivation?
Triggers implicated in HSV reactivation In the context of human disease, exposure to sunlight, psychological stress, fever, menstruation and surgical resection have all been associated with HSV reactivation (Chida and Mao, 2009, Hayderi et al., 2013, Padgett et al., 1998, Roizman and Whitley, 2013).
Where is hsv2 latent?
These data imply that HSV-2 latent infection of the TG is preferentially established in KH10-positive neurons, with a pattern of infection significantly different from that observed with HSV-1 (P < 0.000001).